ALS CURE PROJECT INC

Programs
ALS Disease Mechanism Research Project
ALS Cure Project continued to fund the Physics based modeling project using the worlds fastest supercomputer at Lawerance Livermore Lab to help idenity and understand the ALS disease mechanism. The initial focus will be on the formation of the aberrant TAR DNA- binding protien 43 TDP-43 inclusions or cluster that transition into pathological, amyyloid-like fibrilsGeographiesNot indicatedDatesJan 1, 2022 – Dec 31, 2022Source990No causes providedNo populations provided–$90KALS In Vitro Model Development Program
ALS Cure Project funded a pilot program to evaluate the applicability of LLNLs Brain-on-chip platform to support an in vitro ALS model recapitulating key disease phenotype. This capability can then be used to probe neuronal function as a readout of efficacy to therapeutic compounds, including those being developed at Prosetta Biosciences.GeographiesNot indicatedDatesJan 1, 2022 – Dec 31, 2022Source990No causes providedNo populations provided–$100KALS Innovation Symposium Research Projects
The ALS Cure Project seeded 2 research project Barrow Neuro and Triparite selected from the ALS Innovation Symposim held virtual on November 17th and December 1stof 2021 that included 115 international ALS researchers from 10 nations where participants worked collaboratively in workshop styled breakouts to create the symposiums product. The event was also co-sponsored by Mitsubishi Tanabe Pharma America MTPAGeographiesNot indicatedDatesJan 1, 2022 – Dec 31, 2022Source990No causes providedNo populations provided–$50K
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