Programs

  • Synthetic Innate Immunity Program

    The Synthetic Innate Immunity program aims to develop medicines that serve as society's first line of defense against emerging viral outbreaks by taking inspiration from natural mechanisms of innate immunity. By encoding natural or engineered pattern recognition receptors (PRRs) and interferon-stimulated genes (ISGs) in DNA delivered to the respiratory tract, the program works to persistently enhance a patient's natural sense-and-respond capacity, potentially providing prophylactic protection against a broad range of respiratory viruses for months. During the reporting period, the program achieved several key milestones: developing assays for testing antiviral activities of drug candidates, establishing capacity to deliver nucleic acids to mice, and developing capability to conduct influenza viral challenge studies in mice.
    Geographies
    Not indicated
    Dates
    Jun 29, 2023 – May 31, 2024
    Source
    990
    No causes provided
    No populations provided
    –
    $543K

  • Program 1 [2025]

    The Synthetic Innate Immunity program aims to develop medicines that serve as society's first line of defense against emerging viral outbreaks by taking inspiration from natural mechanisms of innate immunity. By encoding natural or engineered pattern recognition receptors PRRs and interferon-stimulated genes ISGs in DNA delivered to the respiratory tract, the program works to persistently enhance a patient's natural sense-and-respond capacity, potentially providing prophylactic protection against a broad range of respiratory viruses for months.
    Geographies
    Not indicated
    Dates
    Jun 1, 2024 – May 31, 2025
    Source
    990
    No causes provided
    No populations provided
    –
    $330.2K

  • Program 2 [2025]

    PAN-2025-001 is a single-site, two-arm, parallel-group superiority randomized controlled trial (RCT) with 1:1 allocation, designed to evaluate whether large language model (LLM) use improves the ability of novice lab participants to independently perform complex biological tasks. Participants attempt a fixed sequence of five laboratory obstacles that represent the core skills required to create a virus via reverse genetics with or without LLM assistance.
    Geographies
    Not indicated
    Dates
    Jun 1, 2024 – May 31, 2025
    Source
    990
    No causes provided
    No populations provided
    –
    $235.7K